Like their Two-Spirit sisters in North America, the muxes are an integral part of Zapotec culture, revered, not reviled.
When I first read about the Muxes, I thought, yessssss - that's me!
There is a wonderful article on advocate.com that is well worth a read
I look forward to the day we in the west can be male but have the status and role of women. I think we are getting there.